Enhanced Postnatal Acquisition of Hypervirulent Group B Streptococcus

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Hypervirulent Clone of Group B Streptococcus Serotype III Sequence Type 283, Hong Kong, 1993–2012

We describe a hypervirulent clone of group B Streptococcus serotype III, subtype 4, sequence type 283, that caused invasive disease with a predilection for meningitis in Hong Kong during 1993-2012. The organism is associated with high mortality and increased summer prevalence and is linked to diseased fish from freshwater fish farms.

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Parallel Evolution of Group B Streptococcus Hypervirulent Clonal Complex 17 Unveils New Pathoadaptive Mutations

Group B Streptococcus (GBS) is a commensal of the gastrointestinal and genitourinary tracts, while a prevailing cause of neonatal disease worldwide. Of the various clonal complexes (CCs), CC17 is overrepresented in GBS-infected newborns for reasons that are still largely unknown. Here, we report a comprehensive genomic analysis of 626 CC17 isolates collected worldwide, identifying the genetic t...

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9 Group B Streptococcus Meningitis

9.1 Introduction Streptococcus agalactiae (Group B Streptococcus, GBS) is a Gram-positive encapsulated bacterium possessing an array of virulence factors that render it capable of producing serious disease in susceptible hosts, in particular the human newborn (Maisey et al., 2008a). Notably, GBS is the leading cause of meningitis in the neonatal period (Brouwer et al., 2010; Thigpen et al., 201...

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Maternal Group B Streptococcus colonisation

Streptococcus agalactiae, commonly known as Group B Streptococcus (GBS), is an important neonatal pathogen known to cause sepsis, meningitis and pneumonia. Australian pregnant women undergo screening during pregnancy in an effort to eradicate GBS before delivery where transmission to the neonate can occur. Preventative treatment includes intrapartum antibiotic prophylaxis and results in widespr...

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 2019

ISSN: 1058-4838,1537-6591

DOI: 10.1093/cid/ciz035